Stage B Prostate Cancer: Correlation of DNA Ploidy Analysis With Histological and Clinical Parameters
from Cancer Control: Journal of the Moffitt Cancer Center
Linda B. Mora, MD, Lynn C. Moscinski, MD, José I. Diaz, MD, Pamela Blair, Alan B. Cantor, PhD, and Julio M. Pow-Sang, MD
Background: The ability to accurately predict tumor behavior and patient survival is a problem in managing patients with prostate cancer. Prognostic variables in predicting death from tumor include prostate-specific antigen (PSA) level, histological grade, and clinical stage. Observer subjectivity is inherent in determining grade and stage; thus, criteria that are more objective are needed to identify patients for
To read the balance of the paper click "here".
[Cancer Research 45, 1418-1423, March 1, 1985]
© 1985 American Association for Cancer Research
NOTE: A full abstract.
Relationship between DNA Ploidy, Glandular Differentiation, and Tumor Spread in Human Prostate Cancer1
Oskar S. Frankfurt2, Joseph L. Chin3, Lenore S. Englander, William R. Greco, J. Edson Pontes and Youcef M. Rustum
Grace Cancer Drug Center [O. S. F., J. L. C., W. R. G., Y. M. R.], Departments of Pathology [L. S. E.], Biomathematics [W. R. G.], and Urologic Oncology [J. L. C., J. E. P.], Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263
DNA ploidy was evaluated by flow cytometry for 45 human prostate carcinomas (34 prostatectomy specimens and 11 biopsies). Twenty tumors (44.4%) contained a distinct aneuploid stem line. All 11 tumors confined to the prostate gland (pathological Stage B) were diploid. The frequency of aneuploidy increased with advancing stage, and most tumors with distant metastases were aneuploid. The degree of glandular differentiation was characterized by the Gleason score. One-third of tumors with a Gleason score of 5 to 6 were aneuploid, whereas over 70% of poorly differentiated tumors with a Gleason score of 9 to 10 were aneuploid. Among diploid tumors, 45.5% were localized carcinomas (Stage B), 36.4% were characterized by invasion outside the prostate (Stage C), and 18.2% formed pelvic nodal or distant metastases (Stages D1 and D2). In nearly two-thirds of patients with aneuploid tumors, pelvic nodal or distant metastases were found. When tumors were classified according to both DNA ploidy and degree of glandular differentiation, then subgroups of tumors with the highest and lowest degree of malignant potential became apparent. Only 7.1% of diploid tumors with a Gleason score of 5 to 6 formed metastases, but 80% of aneuploid tumors with a higher Gleason score (7 to 10) formed metastases. Diploid tumors with higher Gleason scores and aneuploid tumors with lower Gleason scores had intermediate frequencies of metastases. The presence of an aneuploid stem line in prostate carcinomas indicated that the tumor had spread outside the prostate gland or had metastasized. DNA ploidy may be an important prognostic factor for human prostate cancer. DNA ploidy and the degree of glandular differentiation considered together may improve prognostic evaluation of prostate carcinomas.
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September 21, 2008
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