Chemotherapy - General
Chapter 7: The Role of Chemotherapy
Is Anemia of Cancer Different From Chemotherapy-Induced Anemia?
Chemotherapy - General
Chemotherapy, in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer. In popular usage, it usually refers to antineoplastic drugs used to treat cancer or the combination of these drugs into a standardized treatment regimen.
In its non-oncological use, the term may also refer to antibiotics (antibacterial chemotherapy). In that sense, the first modern chemotherapeutic agent was Paul Ehrlich's arsphenamine, an arsenic compound discovered in 1909 and used to treat syphilis. This was later followed by sulfonamides discovered by Domagk and penicillin discovered by Alexander Fleming.
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Chapter 7: The Role of Chemotherapy
When most people think of treatments for cancer, three things come to mind: surgery, radiation therapy, and chemotherapy. In fact, in nearly all cancers, chemotherapy is a mainstay of treatment, and is often one of the first options employed.
However, this has not been the case for prostate cancer, and, until recently, chemotherapy was used only to relieve symptoms associated with very advanced or metastatic disease.With the publication of two studies in 2004 showing that the use of docetaxel (Taxotere) can prolong the lives of men with prostate cancer that no longer responds to hormone therapy,more and more doctors are recognizing the potential benefits of chemotherapy for the men they treat with advanced prostate cancer.
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Is Anemia of Cancer Different From Chemotherapy-Induced Anemia?
Anemia has myriad causes. In patients with cancer, the chief culprits are direct myelotoxicity from antineoplastic drugs and cytokine-mediated inhibition of erythropoiesis.1 A host of other malign influences may also be at work, including bleeding, renal injury, nutrient deficiency, and so on. A single patient may suffer from several causes of anemia simultaneously, and it is not always easy to distinguish these. However, it is important to try: although the physiological consequences of a low hemoglobin level are similar regardless of its origin, treatment differs considerably.
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